Walter E Kaufmann Selected Research

mecasermin (Increlex)

1/2022	Molecular Signatures of Response to Mecasermin in Children With Rett Syndrome.
1/2018	Placebo-controlled crossover assessment of mecasermin for the treatment of Rett syndrome.
3/2014	Safety, pharmacokinetics, and preliminary assessment of efficacy of mecasermin (recombinant human IGF-1) for the treatment of Rett syndrome.

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Walter E Kaufmann Research Topics

Disease

17	Rett Syndrome (Rett's Disorder) 01/2022 - 06/2008
10	Fragile X Syndrome (Martin Bell Syndrome) 01/2022 - 05/2002
5	Neurodevelopmental Disorders 01/2021 - 03/2014
3	Alzheimer Disease (Alzheimer's Disease) 01/2021 - 12/2019
3	Intellectual Disability (Idiocy) 09/2020 - 12/2012
3	Autistic Disorder (Autism) 11/2019 - 06/2008
2	CDKL5 deficiency disorder 11/2021 - 01/2019
2	Inborn Genetic Diseases (Disease, Hereditary) 09/2020 - 10/2016
2	Autism Spectrum Disorder 09/2020 - 01/2017
2	Nervous System Diseases (Neurological Disorders) 10/2019 - 08/2016
2	Epilepsy (Aura) 01/2019 - 01/2017
2	Seizures (Absence Seizure) 06/2017 - 01/2009
2	Neurologic Manifestations (Neurological Manifestations) 08/2005 - 11/2004
1	Vision Disorders (Hemeralopia) 11/2021
1	Pathologic Processes 12/2019
1	Lubs X-linked mental retardation syndrome 01/2019
1	Infections 01/2019
1	Pain (Aches) 02/2017
1	Scoliosis 01/2017
1	Hypokinesia (Bradykinesia) 01/2017
1	Brain Injuries (Brain Injury) 08/2016
1	Dementia (Dementias) 08/2016
1	Dyslexia (Alexia) 03/2016
1	Cardiac Arrhythmias (Arrythmia) 04/2015
1	Gliosis 01/2009
1	Porphyrias (Porphyria) 11/2004
1	Acute Intermittent Porphyria (Porphyria, Acute) 11/2004

Drug/Important Bio-Agent (IBA)

7	Methyl-CpG-Binding Protein 2IBA 01/2020 - 06/2008
5	Pharmaceutical PreparationsIBA 12/2019 - 10/2016
4	N- dimethyl- 2,2- diphenyl- 3- furanmethanamine hydrochloride tetrahydro-NIBA 01/2022 - 12/2019
3	mecasermin (Increlex)FDA Link 01/2022 - 03/2014
3	Sigma-1 ReceptorIBA 01/2022 - 12/2019
2	Cyclin-Dependent Kinases (cdk Proteins)IBA 11/2021 - 01/2019
2	Proteins (Proteins, Gene)FDA Link 09/2020 - 05/2002
2	DNA (Deoxyribonucleic Acid)IBA 09/2020 - 12/2012
2	Biomarkers (Surrogate Marker)IBA 01/2020 - 10/2016
2	Insulin-Like PeptidesIBA 01/2018 - 03/2014
1	Anti-Anxiety Agents (Anxiolytics)IBA 01/2022
1	Psychotropic Drugs (Psychoactive Drugs)IBA 12/2021
1	RNA (Ribonucleic Acid)IBA 09/2020
1	CalciumIBA 12/2019
1	Muscarinic Receptors (Muscarinic Acetylcholine Receptor)IBA 12/2019
1	trofinetideIBA 01/2019
1	Antipsychotic Agents (Antipsychotics)IBA 06/2017
1	ChromatinIBA 01/2017
1	Apolipoproteins E (ApoE)IBA 08/2016
1	Genetic Markers (Genetic Marker)IBA 03/2016
1	Anticonvulsants (Antiepileptic Drugs)IBA 04/2015
1	mouse Mecp2 proteinIBA 03/2014
1	N-Methylaspartate (NMDA)IBA 10/2011
1	N-Methyl-D-Aspartate Receptors (NMDA Receptors)IBA 10/2011
1	Selective Serotonin Reuptake Inhibitors (Serotonin Reuptake Inhibitors)IBA 03/2011
1	Brain-Derived Neurotrophic Factor (BDNF)IBA 03/2011
1	Serotonin Plasma Membrane Transport Proteins (Serotonin Transporter)IBA 03/2011
1	Fluoxetine (Prozac)FDA LinkGeneric 03/2011
1	Inositol (Myoinositol)IBA 01/2009
1	Glutamine (L-Glutamine)FDA Link 01/2009
1	Glutamic Acid (Glutamate)FDA Link 01/2009
1	Metabotropic Glutamate 5 ReceptorIBA 01/2009
1	5' Untranslated Regions (5' UTR)IBA 05/2008
1	Histones (Histone)IBA 08/2005
1	Heme (Haem)IBA 11/2004
1	PorphyrinsIBA 11/2004
1	Hydroxymethylbilane Synthase (Porphobilinogen Deaminase)IBA 11/2004

Therapy/Procedure

2	Therapeutics 01/2020 - 03/2011
2	Drug Therapy (Chemotherapy) 11/2019 - 01/2019
1	Precision Medicine 01/2020
1	Activities of Daily Living (ADL) 01/2020
1	Resuscitation 08/2018
1	Pain Management 02/2017
1	Gastrostomy 01/2017